Endocrine Abstracts

Background: With the increasing use of cancer immunotherapies in advanced solid organ and hematologic malignancies, endocrinologists are beckoned to manage endocrine complications with unique presentations and natural history in the already challenged oncology patient. We describe four patients illustrating the multifarious endocrine adversities of checkpoint inhibitors.Cases: Patient 1 is a 35-year old male with refractory Hodgkin’s lymphoma, previ...

Objectives: The interplay between thyroid function and metabolic state has been studied in many population subgroups. For pregnant women thyroid and metabolic parameters, including glucose homeostasis, are of great importance for a successful outcome. We examined aspects of thyroid function in relation to GDM and BMI in pregnant women referred to our Department.Methods: We studied 520 women during 24th – 32nd gestation week. De...

Primary Paraganglioma of Thyroid Gland is an extremely rare neuroendocrine tumor. Less than 50 cases have been reported up to date and its rarity is the reason why it’s often mistaken for thyroid nodule or other thyroid neoplasms. In this case we describe the misleading results of ultrasonography followed by FNA-biopsy, which led to a total delay of two years until final diagnosis. A 60 year old female presented with a 38 mm right-sided thyroid module. An ultrasound guide...

Aim: Postoperative calcitonin (postCT) is a prognostic factor for disease progression in MTC patients. We evaluated the disease course in patients with persistently elevated post-CT.Methods: Of all MTC patients (n=273) followed-up in our Unit (for 1–37, median 7 years), 140 (39.3% men, 67.1% sporadicMTCs) had persistently elevated postCT (≥2.0 pg/ml). Clinical and biochemical data were recorded. Patients were classified in four groups...

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy...

Stress is increasingly pervasive in modern society and an unavoidable stimulus to the human organism. Stressors, whether of social or physical type, activate the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the upregulation of glucocorticoid levels and, in some cases, its de novo biosynthesis. Aside from HPA axis regulation, corticosteroids modulate the immune response to inflammation and affect whole-body metabolism. Despite numerous studies using traditional GC-MS...

Purpose: Although the majority of differentiated thyroid cancer (DTC) patients have favorable outcome, approximately up to 20% of them may develop metastatic and/or locoregional disease persistence. One-third of those patients may not respond to the treatment with radioiodine (RAI refractory DTC, RAI-R DTC). There are few reports of real-life experience concerning the clinical course and the treatment modalities that have been used in patients with RAI-R DTC.<p class="abst...

Introduction: Type B insulin resistance is an extremely rare disease with unknown incidence. It is caused by autoantibodies, mostly IgG, against the insulin receptor that in low titres act as partial agonists. This can cause symptoms that include both hypoglycemia and hyperglycemia. It mostly affects middle-aged African-American women and the proposed treatment approaches include plasmapheresis, cyclosporine or cyclophosphamide, steroids and rituximab.Ca...

Background: Gastric neuroendocrine tumors (g-NETs) type I are increasingly recognized and are usually well-differentiated grade 1 neoplasms. However, rare cases of metastatic spread and adverse prognosis have been described in the literature.Aims: The aim of this study was to evaluate the characteristics and the natural history of grade 2 g-NETs type I.Materials and Methods: We collected retrospectively the data of patients with g-...

Aim: To investigate the association of endocrine complications after ICIs immunotherapy with progression free survival (PFS) and overall survival (OS) in a large single-center oncological cohort.Patients and methods: In total, 351 patients were included in the analysis, 248 men (70.7%) and 103 women (29.3%). The median age was 66 years. Patients had a variety of cancer types, namely bladder cancer (131, 37.3%), renal cancer (89, 25.4%), lung cancer (74, ...